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## Section: New Results

### High throughput automated detection of axial malformations in Medaka fish embryo

Participant: Hugues Talbot (Collaboration: Diane Genest, Élodie Puybareau, Jean Cousty, ESIEE Paris, Marc Léonard, Noémie de Crozé, L'Oréal Recherche)

Fish embryos are used throughout the cosmetics industry to assess the toxicity of the components of their products, as well as more generally in waterways pollution measurements. Indeed pollution is often detectable in trace amounts when they hinder, stop or cause malformations during fish embryo development. In this work, we propose a high-throughput procedure for detecting most important malformations in fish embryo. For examples those affecting the tail or the eyes, based on image analysis and machine learning [16]. We have also proposed an atlas-based automated procedure for detecting swim bladder malformations, which are very difficult to assess manually [39].

These malformation are among the most difficult to assess but very common in various degrees of severity. Our procedure provide similar error rate as trained and careful humans operators, as assessed on thousands of images acquired in partneship with L'Oréal. We also show that our procedure is much faster and more consistent than human operators. It is now used in production by our partner.