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Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery

Erythropoiesis, the process of production of red blood cells, is performed through complex regulatory processes. We proposed an earlier model describing stress erythropoiesis in mice [33]. This model, based on the description of erythroid progenitor and erythrocyte dynamics using delay equations, led us to conclude on the quantitative importance of self-renewal. In [6], we refined this previous approaches by taking into account a more mechanistic description of the induction of anemia via phenylhydrazine injection. This led us to revisit some of our initial hypothesis regarding self-renewal regulation.